WebDec 13, 2002 · Here we found that DNA damage enhanced the interaction between Pin1 and p53, which depended on the WW domain in Pin1 and Ser(33/46)-Pro motifs in p53. … WebAug 15, 2014 · Pin1-regulated prolyl-isomerization of the Notch proteins results in dephosphorylation of Notch1 and Notch4 by the PP2A phosphatase, preventing Fbw7α …
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WebThe stability and activity of tumor suppressor p53 are tightly regulated and partially depend on the p53 proline-rich domain (PRD). We recently analyzed mice expressing p53 with a deletion of the PRD (p53 ΔP). p53 ΔP, a weak transactivator hypersensitive to Mdm2-mediated degradation, is unable to suppress oncogene-induced tumors.This phenotype … WebDec 24, 2024 · The interaction of mutant p53 and p63 modulates cell migration and invasion by promoting recycling and signaling of cell surface receptors such as the epithelial growth factor receptor (EGFR) and the hepatocyte growth factor receptor (HGFR) [ 41 ]. simplified exports
Frontiers Tumor Protein 53-Induced Nuclear Protein 1 Enhances …
WebJul 12, 2011 · The genetic interaction between Pin1 and mutant p53 revealed above, prompted us to dissect the underlying mechanisms. Notably, Pin1 coimmunoprecipitated with p53 in tumor samples from p53 M/+ Pin1 +/+ mice (Figure S1C). Given that Pin1 specifically recognizes phosphorylated S/T-P motifs on its substrates, our observation … WebDec 13, 2002 · Since the Pin1 and p53 interaction is enhanced after DNA damage, we next examined the effects of irradiation on the ability of Pin1 to enhance the p21 promoter. As … WebJan 1, 2012 · Protein Interaction Network Analysis (PINA) platform is an integrated platform for protein interaction network construction, filtering, analysis, visualization and … raymond labas washington post